知识图谱可视化分析中医药防治绝经后骨质疏松

背景：中医药防治绝经后骨质疏松症有着悠久的历史，相关领域内研究逐步发展壮大，但目前针对该领域内研究文献的发表情况、核心作者、研究力量等要素分析及系统综述较少。

目的：针对中医药防治绝经后骨质疏松症的相关文献研究进行CiteSpace 知识图谱绘制及可视化分析，了解该领域研究过程、研究热点、发展趋势，为其后续发展提供依据与可行性建议。

方法：计算机检索中国知识基础设施工程(CNKI)数据库1993 至2019年关于中医药防治绝经后骨质疏松症的相关文献，统计分析纳入文献年度发文量、科研基金资助情况、高频被引文献等，并将纳入文献以RefWorks 格式导出使用CiteSpace V 软件生成发文机构、作者、关键词等信息的知识图谱，进行可视化分析。

结果与结论：①共纳入453 篇文献，该领域研究自1993年开展并逐渐获得重视，研究文献以期刊论文为主要形式；②各类科研基金中以国家自然科学基金的资助项目最多；③核心作者有12 人，主要研究者有郑洪新、梁文娜、葛建荣等，并形成相应的主要研究团队；④主要研究机构有广州中医药大学附属骨伤科医院、辽宁中医药大学等中医药院校及其附属医院；⑤研究形成了9个具有代表性的关键词聚类，并随时间推移呈现研究方向的转变趋势；⑥由以上分析可见，中医药防治绝经后骨质疏松症的相关研究历经20 余年，形成多个研究力量、研究主题，其发展仍处于上升期；如能从国家发展战略高度整合优势资源，促进不同地区、机构合作，进一步发掘中医药特色，有望促进中医药走向世界，兴旺发展。

国家自然科学基金()，项目负责人：王建伟

BACKGROUND:Traditional Chinese medicine (TCM) has a long history of preventing and treating postmenopausal the social development,research in relevant fields is gradually ,there are few analysis and systematic reviews regarding publications,core authors,and research strength in this field.

OBJECTIVE:Using visualization method of CiteSpace knowledge map to analyze the relevant literature about prevention and treatment of postmenopausal osteoporosis with TCM,to understand the development,research hot spots and trend of this field,and to offer evidence and advice for the subsequent development.

METHODS:The relevant literature about prevention and treatment of postmenopausal osteoporosis with TCM (1993-2019) was retrieved from CNKI and exported in Refworks analyzed the annual number of papers published,scientific research funding,and high-frequency cited V software was used to create knowledge maps of the authors,research institutions and keywords,for visualization analysis.

RESULTS AND CONCLUSION:A total of 453 articles were research of this field started from 1993 and was gradually articles were the main form of research literature in this Science Foundation of China was the most financial were 12 core authors in this Hongxin,Liang Wenna,and Ge Jianrong were the main researchers who established their own research team.The most important research institutions included Orthopaedic Hospital Affiliated to Guangzhou University of Chinese Medicine and Liaoning University of TCM.Nine typical clusters of keywords were formed and there was a shift in research conclude,the research on the prevention and treatment of postmenopausal osteoporosis with TCM have been developed for over 20 years and is still on the rise with the formation of multiple research forces and research is expected to promote and boom the development of TCM by integrating the research of TCM into national development strategies,by strengthening cooperation between regions and institutions,and by exploiting the characteristics of TCM.

0 引言 Introduction

绝经后骨质疏松症 (postmenopausal osteoporosis，PMOP)是主要发生于绝经后女性的常见骨骼疾病，属Ⅰ型原发性骨质疏松症，其发病机制是由于雌激素的缺乏导致骨量下降，继而出现骨微结构破坏，骨脆性增加。严重的绝经后骨质疏松症易发生骨折以及由骨折引起的疼痛、骨骼变形，甚至死亡。随着中国社会老龄化发展，其发病率和疾病带来的家庭与社会负担正逐渐增加，已成为重要的公共卫生问题[1]。骨质疏松症在中医接近于“骨萎”(“腰背不举，骨枯而髓减”)、“骨痹”(“腰背疼痛，全身骨痛，身重、四肢沉重难举”)，在上千年的中医临证中，根据“肾主骨”“脾主肌肉”及“气血不通则痛”等理论，其治疗多以补肾益精、健脾益气、活血祛瘀为基本治法[2-3]。现代研究证实，多种成分明确的中成药可用于防治骨质疏松症[4-8]。中医药防治绝经后骨质疏松症疗效肯定，国内相关研究日益增多。CiteSpace软件可演算某个研究领域内的研究动向，并以动态多元化的可视化图谱方式展现领域内的研究结构，受到广大研究者的关注[9-12]。该研究基于中国知识基础设施工程(CNKI)数据库，采用CiteSpace V软件对中医药防治绝经后骨质疏松症的研究文献进行可视化分析并绘制知识图谱，以直观了解该领域的研究历史与现状、知识基础来源、研究热点、研究力量空间分布等信息，为今后进一步研究提供文献依据。

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